On almost any map ive done this, and as long as your smart enough to run away when you see your in trouble BEFORE its too late you wont lose everything without getting anything
Heres what i do:I buy a stealth tank, stealth black hand, and a nuke.
I drive into the enemy base when i see a safe opening through the gdi tanks
Once in the base if my vehicle is spotted by too many people i leave it at the exit of the nearest building (not doorway, those are mined, i mean the nearest building edge that provides safety from the agt) and run to safety
I always wait a while before setting the nuke, if you just set it once your safe everyones gonna know which building to check - i always see if i can get to a new building first or i just wait till things calm down, then i set the c4 then i promptly set the nuke on top of it (or the other way around)
I then proceed to stand near it and defend it, if i see an engy coming i move overtop of it, if its just a trooper i wait till they turn there ugly head and i shoot it off for them.
The c4 helps A LOT because if its set ON the beacon it makes it harder for them to find the beacon to disarm, if you set it BEFORE you set the beacon it will blow up half way through and kill an engie or two if you died defending it
Like i said, hasnt failed me yet